CHOICE2 randomized 400 patients across 14 Spanish centers to thrombectomy alone versus thrombectomy plus intraarterial alteplase, with 90-day mRS as the primary endpoint. Excellent outcomes (mRS 0–1) ...

Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic stroke. Tenecteplase, which is more fibrin-specific and has longer activity than alteplase, is ...

Administering intra-arterial tissue plasminogen activator (tPA; alteplase) after successful thrombectomy boosts outcomes in patients with acute ischemic strokes caused by large-vessel occlusions, the ...

Giving the clot-busting medication alteplase at the site of a blocked brain artery after blood clot removal may increase the number of patients who fully recover, according to preliminary ...

Intra-arterial (IA) alteplase was associated with superior 90-day functional outcomes than standard therapy alone in Chinese patients with large-vessel occlusion (LVO) stroke who had achieved ...

We conducted a trial at 41 academic tertiary care centers in China to evaluate endovascular thrombectomy with or without intravenous alteplase in patients with acute ischemic stroke. Patients with ...